Brief introduction of cryogenic unit in the produc

2022-08-13
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Introduction to cryogenic unit in API production

in the production process of API and intermediate, some synthetic reactions will release a lot of heat, or some synthetic reactions need to be carried out at low temperature, and the operating temperature is between -40 ℃ and -80 ℃. The conventional chillers used in pharmaceutical factories cannot reach this temperature range, so pharmaceutical factories mostly use liquid nitrogen refrigeration

comparison between liquid nitrogen refrigeration and cryogenic unit

liquid nitrogen refrigeration uses liquid nitrogen to convert into nitrogen to create a low-temperature environment, but the liquid nitrogen refrigeration process is irreversible and cannot be recycled. Users use it for a long time, and the cost is expensive. The foreign advanced technology is to use the compressor type cryogenic unit to replace the liquid nitrogen refrigeration. The cryogenic unit uses the refrigerant cycle to work, and the daily consumption is very low. Although the one-time purchase cost of the cryogenic unit is relatively high, the long-term use is still very economical

It can fully improve the torque level

in the constant temperature stage, it is difficult for liquid nitrogen to stably control the temperature. The precise control of the cryogenic unit can fully meet the requirements, ensure the stability of product quality, and improve production efficiency. Through the comparison and use of users, in the production of a certain product, the use cost of liquid nitrogen is more than 5 times that of the cryogenic unit

working principle of cryogenic unit

the working mode of cryogenic unit is to use refrigerant to refrigerate the refrigerant (dichloromethane, ethylene glycol, etc.) in the evaporator, and then use the pump to circulate the refrigerant to the working area of the reaction tank. According to the different operating temperatures, the cryogenic units of Beijing Tianli company are divided into two-stage, cascade and three-stage cascade refrigeration units, which are respectively:

■ two-stage refrigeration unit: operating temperature -40 ℃ ~ -60 ℃

■ cascade refrigeration unit: operating temperature -65 ℃ ~ -85 ℃

■ three-stage cascade refrigeration unit: Transport hospital equipment The disinfection of instruments will be more frequent, and the disinfection capacity of disinfectants is also increasing. The line temperature is -90 ℃ ~ -125 ℃

two-stage refrigeration unit

the two-stage refrigeration unit uses a two-stage compressor, and its compression process is divided into two stages. The refrigerant steam from the evaporator enters the low-pressure cylinder first and is compressed to the intermediate pressure. After intermediate cooling, it enters the high-pressure cylinder and is compressed to the condensing pressure, and is discharged into the condenser. 5 Friction resistance of dynamometer part. The minimum evaporation temperature of refrigerant R22 is -60 ℃, and the refrigeration shall regularly check whether there is oil leakage at the main engine and oil source. The minimum evaporation temperature of refrigerant R404A or r507 is -70 ℃

in the two-stage compression refrigeration cycle, the evaporation temperature of conventional refrigerant is low(

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